杨睿

作者: 时间:2021-04-07

杨睿致公党员,博士,教授,士生导师

Email: yangrui9111@163.com or yangrui@kust.edu.cn

1991.09-1995.07 云南工业大学 化学工程专业 学士

2003.09-2006.07 云南大学 有机化学专业 硕士

2008.09-2012.12 云南大学 有机化学专业 博士

2018.12-2019.12 俄亥俄州立大学 生物化学专业 访问学者

 

本科:《有机化学A》、《有机化学B》、有机合成

研究生:有机合成

 

主要研究方向

1. 设计构筑环境友好超分子及复合纳米材料的绿色有机反应催化体系;

2. 开发结构新颖的功能化超分子主体及有序自组装体

3. 设计构建一珠二物多肽库,筛选靶向蛋白质-蛋白质//受体的穿膜多肽。

承担科研项目及完成情况

1. 企业技术攻关项目,板材挥发性气味成份及除味剂成份分析检测主持

2. 企业技术攻关项目,板材挥发气味分析检测主持

3. 企业技术攻关项目,鱼肉食品防腐剂的开发主持

4. 企业技术攻关项目,水溶性抗肿瘤药物分子的合成及活性研究主持

5. 省级项目(人培),基于环糊精接枝手性分子的新型催化剂的制备及其在有机合成反应中的应用主持

 

获奖情况:

2011红云园丁奖

2022年指导本科生参加第三届全国老员工化学实验创新设计大赛,获“微瑞杯”西南赛区一等奖

代表性教材,论文和专著:

[1] Marina Buyanova, Ashweta Sahni, Rui Yang, Amar Sarkar, Heba Salim, Dehua Pei*. Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency, Molecular Pharmaceutics, 2022, 19, 5, 1378-1388.

[2] Bin Deng, Jing Yang, Mengbi Guo, Rui Yang*. Highly efficient catalytic performance on CuAAC reaction by polymer-like supramolecular self-assemblies-Cu (I) in aqueous solution, Applied Organometallic Chemistry, 2022, 36, 6, e6674.

[3] Xuepu Feng, Fen Zhao, Rui Qian, Mengbi Guo, Jing Yang, Rui Yang*, DongLing Meng*. Supramolecular Catalyst Functions in Catalytic Amount: Cucurbit[7]uril Accelerates Click Reaction in Water, ChemistrySelect, 2021, 6, 40, 10739-10745.

[4] Marina Buyanova, Shurui Cai, Jahan Cooper, Curran Rhodes, Heba Salim, Ashweta Sahni, Punit Upadhyaya, Rui Yang, Amar Sarkar, Na Li, Qi-En Wang, Dehua Pei*. Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor, Journal of Medicinal Chemistry, 2021, 64, 17, 13038-13053.

[5] Xuepu Feng, Yafei Guo, Rui Qian, Bin Deng, Zhen Chen, Bo Yang*, Rui Yang*. Immobilized b-cyclodextrin and palladium-pyridylaldehyde complex on silica nanoparticles as a highly active catalyst for Suzuki, reduction of nitroarenes and oxidative amination of aldehydes reactions in water, Materials Today Communications, 2021, 26, 101909.

[6] Xuepu Feng, Xin Na, Yafei Guo, Rui Qian, Jianqiang Zhang, Zhen Chen, Rui Yang*. Host-guest inclusion system of 1, 2-O, O-Diacetyllycorine (DALY) and a-Cyclodextrin: Preparation, characterization, inclusion modes and anticancer activity, Journal of Molecular Structure, 2019, 1181, 467-473.

[7] Kaixiu Luo, Lu Zhang, Rui Yang*, Yi Jin*, Jun Lin*. Picolinamide modified b-cyclodextrin/Pd (II) complex: A supramolecular catalyst for Suzuki-Miyaura coupling of aryl, benzyl and allyl halides with arylboronic acids in water, Carbohydrate Polymers, 2018, 200, 200-210.

[8] Rui Yang*, Chuanfan Xiao, Yafei Guo, Min Ye*, Jun Lin*. Inclusion complexes of GA3 and the plant growth regulation activities, Materials Science & Engineering C-Material for Biological Applications, 2018, 91, 475-485.

[9] Dandan Liu, Yafei Guo, Jianqiang Zhang, Zhikuan Yang, Xiang Li, Bo Yang, Rui Yang*. Inclusion of Lycorine with natural Cyclodextrins (a-, b- and g-CD): Experimental and in vitro evaluation, Journal of Molecular Structure, 2017, 1130, 669-676.

[10] Yafei Guo, Jiuling Li, Xiwei Shi, Yang Liu, Kai Xie, Yuqi Liu, Yubo Jiang, Bo Yang, Rui Yang*. Cyclodextrin supported palladium complex: as a highly active and recoverable catalyst for Suzuki-Miyaura cross-coupling reaction in aqueous medium, Applied Organometallic Chemistry, 2017, 31, e3592.

[11] Yafei Guo, Jiuling Li, Yuqi Liu, Yongping Ma, Huilin Cheng, Bo Yang*, Dandan Liu*, and Rui Yang*. Inclusion complexes of anhydrolycorine with cyclodextrins:preparation, characterization, and anticancer activity, Canadian Journal of Chemistry, 2016, 94, 1-8.

[12] Yafei Guo, Yushun Zhang, Jiuling Li, Fen Zhao, Yang Liu, Min Su, Yubo Jiang, Yuqi Liu, Jihong Zhang*, Bo Yang*, and Rui Yang*. Inclusion Complex of Podophyllotoxin with γ-Cyclodextrin: Preparation, Characterization, Anticancer Activity, Water-Solubility and Toxicity, Chinese Journal of Chemistry, 2016, 34, 425-431.

[13] Yafei Guo, Jiuling Li, Fen Zhao, Guineng Lan, Liang Li, Yuqi Liu, Yunsen Si, Yubo Jiang, Bo Yang, Rui Yang*. Palladium-modified functionalized cyclodextrin as an efficient and recyclable catalyst for reduction of nitroarenes, RSC Advances, 2016, 6, 7950-7954.

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